Benefits of TIENS Grape Extract. Discover the multi-faceted health benefits of TIENS Grape Extract: from antioxidant and cardiovascular support to skin health and digestion—backed by science and traditional wisdom.TIENS Grape Extract, often marketed under the name Cholikan, is a dietary supplement blending several ingredients noted for their antioxidant, cardiovascular, and skin-supporting benefits. The formulation typically includes:
- Grape seed extract rich in oligomeric proanthocyanidins (OPCs) and resveratrol
- Vitamin C, a powerful antioxidant and collagen supporter
- Fructooligosaccharides (from chicory), a prebiotic fiber
- Black pepper extract standardized for piperine, to enhance nutrient absorption
Together, these ingredients aim to support overall health, focusing on anti-aging, immune function, and metabolic wellness.
1. Powerful Antioxidant Defense
Grape seed extract is celebrated for its high concentration of polyphenols, especially OPCs and resveratrol—both potent antioxidants. These compounds help neutralize free radicals that cause oxidative stress, a key factor in cellular aging and chronic disease
Vitamin C complements this effect by further protecting cells from oxidative damage and supporting immune resilience and collagen synthesis for vascular and skin health
2. Cardiovascular Support
Resveratrol and grape-derived flavonoids have been linked to heart health benefits. Research confirms that resveratrol supports cardiovascular function, including maintaining blood vessel flexibility and healthy blood flow
Meta-analyses suggest that grape seed extract can significantly lower:
- LDL (“bad”) cholesterol
- Total cholesterol
- Triglycerides
- C-reactive protein (CRP), an inflammation marker
The anti-inflammatory and lipid-lowering actions may contribute to overall cardiovascular protection.
3. Blood Pressure and Circulation Benefits
Another meta-analysis indicates that grape seed extract, at daily doses under 800 mg for at least 8 weeks, may reduce systolic and diastolic blood pressure—especially in individuals with metabolic syndrome—showing average systolic reductions of around 8.5 mmHg
Additionally, user-shared insights highlight benefits in microcirculation and vein health:
“GSE … increased capillary resistance … alleviated … swelling, itching, pain and heaviness in the legs”
These anecdotal observations complement the clinical data.
4. Skin Health and Anti-Aging Effects
TIENS Grape Extract may also enhance skin health. Vitamin C supports collagen production, while OPCs and resveratrol improve skin elasticity and protection from oxidative damage, potentially slowing visible signs of aging
Preclinical data on specific components like procyanidin C1 (PCC1) are promising: in mice, PCC1 helped clear senescent (aging) cells, extending lifespan and improving physical performance, hinting at anti-aging potential While exciting, these findings remain preliminary and not yet validated in humans.
5. Digestive Health and Nutrient Absorption
Chicory-derived fructooligosaccharides serve as prebiotics—they nourish beneficial gut bacteria, promoting digestive health, better immunity, and improved absorption of minerals like calcium and iron (from product descriptions).
Piperine from black pepper enhances bioavailability of many compounds (including resveratrol and vitamin C), helping the body absorb and utilize these nutrients more effectively .
6. Safety and Side Effects
Grape seed extract is generally well tolerated. Mild side effects can include itchy scalp, dizziness, headache, or nause
Caution is advised for individuals on blood-thinning medications; grape seed extract may potentiate bleeding risk due to its mild anticoagulant effects—consult your doctor before use.
Some skeptics urge caution regarding claims of anti-cancer effects—there is no clinical proof that grape seed extract can cure or treat cancer.
Summary Table: Key Benefits of TIENS Grape Extract
| Benefit | Mechanism / Evidence |
|---|---|
| Antioxidant protection | Rich in OPCs, resveratrol, and vitamin C—defending cells from free radicals |
| Cardiovascular support | Improves blood lipids, reduces inflammation, supports vascular health |
| Blood pressure/circulation | Lowers blood pressure; improves capillary resistance and vein health |
| Skin & anti-aging | Enhances collagen and elasticity; potential senolytic action (preclinical) |
| Digestive & nutrient support | Prebiotics + piperine enhance gut health and absorption of nutrients |
| Safety considerations | Generally mild side effects; caution with blood thinners and unverified claims |
Conclusion
TIENS Grape Extract (Cholikan) presents a thoughtfully blended supplement offering antioxidants, cardiovascular support, skin care benefits, digestive enhancement, and nutrient absorption assistance. Clinical research and user experiences suggest its potential to aid lipid profiles, blood pressure, skin aging, and circulation.
That said, it’s essential to approach its benefits realistically—clinical confirmations (particularly in humans) are limited, and medical advice should be sought if you’re taking medications or have health concerns.
References
Bagchi, D., Bagchi, M., Stohs, S., Das, D. K., Ray, S. D., Kuszynski, C. A., … & Preuss, H. G. (2000). Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology, 148(2-3), 187–197. https://doi.org/10.1016/S0300-483X(00)00202-9
Basu, A., & Penugonda, K. (2009). Pomegranate juice: A heart-healthy fruit juice. Nutrition Reviews, 67(1), 49–56. [Note: included as reference for polyphenols and cardiovascular health] https://doi.org/10.1111/j.1753-4887.2008.00133.x
Chacón, M. R., & Ceperuelo-Mallafré, V. (2022). Role of Resveratrol in Human Health: Mechanisms of Action and Clinical Perspectives. International Journal of Molecular Sciences, 23(21), 13485. https://doi.org/10.3390/ijms232113485
Healthline. (2023). 10 Health Benefits of Grape Seed Extract, Based on Science. https://www.healthline.com/nutrition/grape-seed-extract
Nassiri-Asl, M., & Hosseinzadeh, H. (2016). Review of the Pharmacological Effects of Vitis vinifera (Grape) and Its Bioactive Compounds. Phytotherapy Research, 30(4), 540–570. https://doi.org/10.1002/ptr.5591
Sano, A., Uchida, R., Saito, M., Shioya, N., Komori, Y., Tho, Y., & Hashizume, N. (2007). Beneficial effects of grape seed extract on malondialdehyde-modified LDL. Journal of Nutritional Science and Vitaminology, 53(2), 174–182. https://doi.org/10.3177/jnsv.53.174
TIENS Group. (2025). TIENS Grape Seed Extract (Cholikan) Product Description. TIENS Official Website. https://mk.tiens.com/products/foodsupplement/tiensgrapeseedextractcapsules/
TIENS Group. (2025). Product details – TIENS Grape Seed Extract with Resveratrol, Vitamin C, and Black Pepper. https://ke.tiens.com/products/foodsupplement/tiensgrapeseedextractcapsules/
Wikipedia. (2025). Grape seed extract. Retrieved from https://en.wikipedia.org/wiki/Grape_seed_extract
Zare, R., Nadjarzadeh, A., Zarshenas, M. M., Shams, M., & Heydari, M. (2020). Efficacy of grape seed extract for blood pressure and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine, 51, 102430. https://doi.org/10.1016/j.ctim.2020.102430
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